Fertility was not affected in mice or rats. Oral administration of nicardipine was neither embryotoxic nor teratogenic but did cause dystocia, decreased birth weights, and decreased neonatal survival. Intravenous administration of nicardipine (dihydropyridine) was embryotoxic (rats, rabbits) but not teratogenic.
In rats, nimodipine produced embryotoxicity but no signs of teratogenicity and had no effect on fertility. Oral administration of nimodipine (dihydropyridine) to rabbits was teratogenic and produced stunted fetuses. A dose-related increase in mammary size occurred in rabbits administered felodipine. There was no effect on fertility in rats. Felodipine prolonged parturition, made labor more difficult, and caused an increased frequency of fetal and early postnatal deaths. Oral administration of felodipine (dihydropyridine) to rats had no effect on fertility parameters but did cause teratogenic effects (digital anomalies) in both rats and monkeys.
Fertility in male and female rats was unaffected. Peri- and postnatal administration of isradipine to rats resulted in decreased maternal weight gain and reduced birth weight and survival of the pups. There was no evidence of embryotoxicity at doses that were not maternally toxic and no evidence of teratogenicity. Oral administration of isradipine (dihydropyridine) was associated with decreased maternal weight gain (rats and rabbits) and an increase in fetal resorptions (rabbit). Amlodipine prolonged gestation and the duration of labor. However, litter size was decreased (∼50%) and the number of intrauterine deaths was increased in rats dosed with amlodipine prior to and throughout mating and gestation. Nifedipine prolonged pregnancy and caused a reduction in neonatal survival (rats).Īmlodipine (dihydropyridine) exhibited no signs of teratogenicity or embryo/fetal toxicity when administered orally to pregnant rats and rabbits during the period of organogenesis. It was considered to be teratogenic in rats and rabbits (digital anomalies, rib deformities, cleft palate), and embryotoxic and fetotoxic (stunted fetuses) in rats, mice, rabbits, and monkeys. Nifedipine (dihydropyridine) was associated with a reduction in fertility in rats. Gad, in Encyclopedia of Toxicology (Third Edition), 2014 Reproductive and Developmental Toxicity Nifedipine 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-,dimethyl ester adalat adalat crono adalate adalat pa adalat retard aldipin angibloc aponifed aprical aprical retard bay 1040 bay a 1040 calcigard chronadalat chronadalate coracten cordafen cordaflex cordicant cordipin corinfar corotrend depin 1,4 dihydro 2,6 dimethyl 4(2 nitrophenyl) 3,5 pyridinedicarboxylic acid dimethyl ester 1,4 dihydro 2,6dimethyl 4 (2 nitrophenyl)pyridine 3,5 dicarboxylic acid dimethyl ester dimethyl 1,4 dihydro 2,6 dimethyl 4 (2 nitrophenyl) pyridine 3,5dicarboxylate 2,6 dimethyl 4 (2 nitrophenyl) 1,4 dihydro 3,5pyridinedicarboxylic acid dimethyl ester duranifin ecodipin emaberin fenigidin herlat infedipine mifedipine moderat myogard nifangin nifedicor nifedicor gocce nifedine nifedipat nifedipinum nifehexal nifelat nifensar nifepidine nifical nificard 4 (2 nitrophenyl) 2,6dimethyl 3,5 dicarbomethoxy 1,4 dihydropyridine 4 (2' nitrophenyl) 2,6dimethyl 3,5 dicarbomethoxy 1,4 dihydropyridine novonifedin phenygidine pidilat pidilat retard procardia procardia xl ronian sepamit slofedipine slofedipine xl unidipine zenusin 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-, dimethyl ester 1,4 dihydro 2,6 dimethyl 4 (2 nitrophenyl) 3,5 pyridinedicarboxylic acid dimethyl ester 1,4 dihydro 2,6 dimethyl 4 (2 nitrophenyl)pyridine 3,5 dicarboxylic acid dimethyl ester 2,6 dimethyl 4 (2 nitrophenyl) 1,4 dihydro 3,5 pyridinedicarboxylic acid dimethyl ester 4 (2 nitrophenyl) 2,6 dimethyl 3,5 dicarbomethoxy 1,4 dihydropyridine 4 (2' nitrophenyl) 2,6 dimethyl 3,5 dicarbomethoxy 1,4 dihydropyridine bay a1040 bay1040 dimethyl 1,4 dihydro 2,6 dimethyl 4 (2 nitrophenyl) pyridine 3,5 dicarboxylate Tippens, in xPharm: The Comprehensive Pharmacology Reference, 2007